HAP2 — Schizosaccharomyces pombe 972h-

Summary

SPBC725.11C (HAP2, php2) on chromosome 2 of Schizosaccharomyces pombe encodes a CCAAT-binding factor subunit of the NF-YA family. The protein possesses promoter-enhancer loop anchoring activity, RNA polymerase II core promoter sequence-specific DNA binding, and DNA-binding transcription activator activity. HAP2 is associated with the regulation of aerobic respiration, carbon catabolite repression, TCA cycle, iron-sulfur cluster assembly, kinetochore assembly, nucleosome assembly, homologous recombination, meiosis, and chromatin modeling. It localizes to the nucleus and heterochromatin. Phenotypic associations link HAP2 to increased respiratory and fermentative metabolism, increased viability and stationary phase survival, increased hydrostatic pressure and osmotic stress resistance, decreased cold sensitivity and apoptosis, altered cell cycle progression, abnormal sporulation, and increased mitophagy. The gene is also connected to HAP3, HAP4, HAP5, and TOR1. Related genes in other species are linked to protein secretion and chitin deposition.