GLC7 — Schizosaccharomyces pombe 972h-

Summary

SPBC776.02C (GLC7, dis2) on chromosome 2 encodes a serine/threonine-protein phosphatase catalytic subunit, a type 1 protein phosphatase (PP1) with RNA polymerase II C-terminal domain T4 phosphatase activity and metal binding. It is associated with mitotic metaphase/anaphase transition, chromosome separation, spindle breakdown, and sister chromatid separation. The gene is linked to regulation of glycogen anabolism, clathrin-mediated endocytosis, cell budding, anisotropic cell growth, cell polarization, and centromere clustering. It localizes to the PTW/PP1 phosphatase complex, protein phosphatase type 1 complex, cellular bud neck septin collar, mating projection base, cell cortex, CENP-A-containing chromatin, euchromatin, and spindle pole body. Phenotypic associations include abnormal cell cycle progression, premature meiosis, absent spore wall formation, altered budding patterns, and defects in chromosome segregation, autophagy, pexophagy, and nuclear import.