ARK1 — Schizosaccharomyces pombe 972h-

Summary

SPBC8D2.01 (ARK1, also known as gsk31) on chromosome 2 of Schizosaccharomyces pombe encodes a GSK-3 family protein kinase with serine/threonine and dual-specificity kinase activity, including CDK and ERK1-type activity. The gene is associated with regulation of chromosome segregation, centrosome duplication, chromosome biorientation, and sister chromatid segregation. It is linked to positive regulation of phospholipid anabolism, negative regulation of phosphate metabolism and glycogen anabolism, and downregulation of calcium-mediated signaling and macroautophagy. The protein localizes to the cytoplasm, nucleus, cytosol, cellular bud neck, and CDK holoenzyme complexes. Phenotypic associations include delayed cell cycle progression in G2 phase, S phase arrest, decreased cytokinesis and endocytosis, abnormal filamentous and pseudohyphal growth, altered mating type switching, increased polyploidy, and decreased necrotic cell death.