RUM1 — Schizosaccharomyces pombe 972h-

Summary

SPBP19A11.06 (RUM1, lid2) on chromosome 2 of Schizosaccharomyces pombe 972h- encodes a protein with histone H3K4 demethylase activity, histone H3K36 demethylase activity, chromatin binding, DNA binding, and zinc binding, and contains ARID, JmjC, PHD, and C5HC2 zinc-finger domains. The gene is associated with heterochromatin organization, RNAi-like chromatin silencing, heterochromatin boundary formation, mating-type switching, sexual reproduction, cell differentiation, and response to nutrient. It is linked to cell cycle control including G1, G2, M phase, metaphase and mitotic exit, as well as chromatin-mediated maintenance of transcription and regulation of gene expression. The product localizes to the nucleus, chromatin, centric heterochromatin, mating-type region heterochromatin, HDAC complex and SWR-C. Related genes in other species are linked to the Lid2 complex.