prp5 — Schizosaccharomyces pombe 972h-

Summary

SPBP22H7.07 (prp5) on chromosome 2 of Schizosaccharomyces pombe encodes a protein containing WD40 repeats, placing it in the Prp46/PLRG1-like family. The gene is associated with the precatalytic spliceosome, Prp19 complex, and catalytic step 2 spliceosome, linking it to pre-mRNA splicing. It is associated with mitotic metaphase, mitotic S phase, G2 phase, premeiotic DNA replication, meiosis II, regulation of mitosis, DNA replication checkpoint, and septin checkpoint. Additional associations include oogenesis, spermatogenesis, embryogenesis, syngamy, actin depolymerization, cell size control, and responses to UV and UV-A. Phenotypic associations include decreased cell cycle progression rate, increased G1 phase progression, decreased G2 phase progression, increased anaphase duration, altered septum formation, increased mating type switching, absent mating efficiency, and abnormal lifespan.