sgo1 — Schizosaccharomyces pombe 972h-

Summary

SPBP35G2.03C (sgo1) on chromosome 2 of Schizosaccharomyces pombe 972h- encodes a chromatin adaptor protein belonging to the Shugoshin family, characterized by Shugoshin_N and Shugoshin_C domains. The gene is associated with centromeric sister chromatid cohesion, centromere localization, and kinetochore assembly, as well as chromosome biorientation and segregation during both mitosis and meiosis. It is linked to the second meiotic division, meiosis II chromosome segregation, and homologous chromosome segregation, alongside spindle attachment to meiosis I kinetochore. The product localizes to the inner kinetochore, centromere complex, centric heterochromatin, meiotic spindle, and nuclear envelope. Associations extend to the spindle assembly checkpoint, DNA replication checkpoint, and anaphase cohesion protection, with connections to prophase and regulation of mitosis.