SMC2 — Schizosaccharomyces pombe 972h-

Summary

SPBP4H10.06C (SMC2, cut14) on chromosome 2 of Schizosaccharomyces pombe encodes a structural maintenance of chromosomes (SMC) family protein with ATP hydrolase and DNA translocase activity, and binds DNA, double-stranded DNA and chromatin. The gene is associated with chromosome condensation, mitotic and meiotic sister chromatid cohesion, centromere separation, spindle elongation, and the spindle assembly checkpoint. It localises to the condensin and cohesin complexes, condensed chromosomes, kinetochore and nucleolus. Phenotypic associations include abnormal cell fusion, colony size, chromosome segregation, cell cycle progression through anaphase and the metaphase-anaphase transition, premature meiosis, absent sporulation efficiency, increased gamma ray resistance and virulence, decreased polyploidy, delayed vegetative growth and mitotic cell cycle, and increased fermentative growth. Studies of related genes in other species link the family to the cohesin complex.