ASP1 — Schizosaccharomyces pombe 972h-

Summary

SPBPB21E7.09 (ASP1) in Schizosaccharomyces pombe 972h- encodes a probable L-asparaginase 3, a member of the asparaginase/glutaminase-like family with asparaginase activity (EC 3.5.1.1). The gene is associated with asparagine and taurine breakdown, as well as diverse cellular processes including cell quiescence, chromosome biorientation, mitochondrion distribution, polyphosphate metabolism, iron-sulfur cluster assembly, spindle assembly checkpoint, polar cell growth, and cell morphogenesis. The encoded protein localises to the cytoplasm, periplasm, and cell-bound compartments. ASP1 is linked to numerous phenotypes including abnormal flocculation, increased adhesion, abnormal colony shape, decreased invasive and filamentous growth, increased vegetative growth rate, increased replicative lifespan, increased stress resistance and thermotolerance, decreased respiratory and fermentative growth, and altered cell cycle progression in G1 phase. Related genes in other species are linked to filamentous growth and UV resistance.