ADE2 — Schizosaccharomyces pombe 972h-

Summary

SPCC1322.13 (ADE2, ade6) on chromosome 3 of Schizosaccharomyces pombe encodes a protein with phosphoribosylaminoimidazole carboxylase activity (EC 4.1.1.21) and ATP-grasp domains, placing it in the Ade2 family of fungi and plants. The gene is associated with purine base and adenine anabolism, de novo IMP anabolism, and glutathione and pigment anabolism. It is linked to heterochromatin organization, plasmid recombination, resolution of recombination intermediates, gene conversion, mitotic recombination, cell differentiation, G2 phase, and RNA breakdown. The product localizes to the cytosol. Phenotypic associations include increased apoptosis, increased mitochondrial rho- mutation frequency, increased exponential growth rate, decreased gamma ray resistance, decreased sporulation, decreased autophagy, decreased freeze-thaw resistance, decreased ionic stress resistance, abnormal cell shape and size, abnormal budding pattern and index, abnormal endoplasmic reticulum and lipid particle morphology, increased killer toxin resistance, increased protein secretion, and absent nitrogen source utilization.