ste6 — Schizosaccharomyces pombe 972h-

Summary

SPCC1442.01 (ste6) on chromosome 3 of Schizosaccharomyces pombe encodes a Ras guanine nucleotide exchange factor (Ras GEF) containing SH3 and Ras GEF catalytic domains. The gene product is associated with guanyl-nucleotide exchange factor activity and is linked to multiple biological processes, including mating, conjugation with cellular fusion, copulation, sporulation, meiosis, and traversing the start control point of the mitotic cell cycle. It is associated with positive regulation of the pheromone response MAPK cascade, Ras protein signal transduction, the adenylate cyclase-activating GPCR signaling pathway, and cellular responses to glucose stimulus and starvation. The protein localises to the plasma membrane, cytoplasm, cytosol, cellular bud, and mating projection actin fusion focus. Studies of related genes in other species link the family to cell cycle control and Ras-mediated signalling.