AFL1 — Schizosaccharomyces pombe 972h-

Summary

SPCC1672.06C (AFL1, also known as asp1) on chromosome 3 encodes a protein with ATP-grasp_RimK-type and VIP1_N domains that has 5-diphosphoinositol pentakisphosphate 1-kinase activity and inositol hexakisphosphate 1-kinase activity (EC 2.7.4.24), also exhibiting inositol diphosphatase and ATP hydrolase activities. The gene is associated with regulation of mitotic spindle elongation, bipolar cell growth, chromosome biorientation, spindle assembly checkpoint, and microtubule dynamics. It is linked to inositol phosphate metabolism, breakdown, and anabolism, as well as polyphosphate metabolism, intracellular Pi homeostasis, and iron-sulfur cluster assembly. Associations include cell cycle progression through metaphase and telophase, cell quiescence, polar cell growth, and intracellular transport. The protein localizes to the cytoskeleton, cytosol, and nucleus. Related genes in other species connect the family to cell cycle regulation.