DO — Schizosaccharomyces pombe 972h-

Summary

SPCC1840.02C (DO, also known as FKS1, GSC1, or bgs4) on chromosome 3 of Schizosaccharomyces pombe encodes a protein with branched 1,3-beta-D-glucan synthase, callose synthase, and alpha-1,3-glucan synthase activities (EC 2.4.1.34). The protein belongs to the Glyco_trans_48 and FKS1-like domain families. DO is associated with cell wall assembly, primary and secondary cell septum biogenesis, contractile ring contraction, ascospore wall glucan anabolism, and regulation of cell polarity. It localises to the primary cell septum, cleavage furrow, spore wall, growing cell tips, and the mitotic actomyosin contractile ring. Phenotypic associations link DO to alkaline pH resistance, spore germination rate, cell cycle progression through G2/M, shmoo formation, adhesion, pexophagy, and fermentative growth. Studies of related genes in other species connect the family to beta-glucan content, sporogenesis, and oxidative stress response.