gad8 — Schizosaccharomyces pombe 972h-

Summary

SPCC24B10.07, also known as gad8, encodes a serine/threonine protein kinase with protein kinase C activity, containing C2 and AGC-kinase domains, and is located on chromosome 3 of Schizosaccharomyces pombe. The gene is associated with diverse biological processes including TORC2 signaling, regulation of response to osmotic stress, downregulation of filamentous growth, and positive regulation of transcription by RNA polymerase III. It is linked to cellular components such as the cytoskeleton, division septum, stress granules, and nuclear envelope. Phenotypic associations include abnormal mating response, decreased budding, increased prion inheritance, delayed cell cycle progression, decreased radiation resistance, and abnormal pseudohyphal growth. The gene is also associated with oxidative stress response and regulation of sphingolipid biosynthesis. Related genes in other species are linked to protein kinase activity and virulence traits.