ark1 — Schizosaccharomyces pombe 972h-

Summary

SPCC320.13C, symbol ark1 on chromosome 3 of Schizosaccharomyces pombe 972h-, encodes a protein serine/threonine kinase with cAMP-dependent protein kinase activity and histone H3S10 kinase activity (EC 2.7.11.1). The product belongs to the Aurora-like kinase family and contains a protein kinase domain. Ark1 is associated with multiple aspects of chromosome and cell division biology, including regulation of chromosome segregation, centrosome duplication, mitotic spindle assembly, and the spindle assembly checkpoint. It localises to kinetochore microtubules, the spindle midzone, and the CPC complex. The gene is linked to meiotic chromosome segregation, repair of kinetochore-microtubule attachment defects, and positive regulation of the mitotic cell cycle spindle assembly checkpoint. Related genes in other species connect this kinase family to chromosome biorientation and the spindle checkpoint.