PYRG — Schizosaccharomyces pombe 972h-

Summary

PYRG (ura4) on chromosome 3 of Schizosaccharomyces pombe 972h- encodes a protein with orotidine-5'-phosphate decarboxylase activity (EC 4.1.1.23) and orotate phosphoribosyltransferase activity, placing it in the OMPdecase family with a TIM barrel domain. This gene is associated with de novo UMP biosynthesis, uracil anabolism, and pyrimidine base anabolism, as well as processes including plasmid recombination, telomere assembly, regulation of mitosis, and response to methyl methanesulfonate. It has been linked to diverse phenotypes such as altered adhesion, decreased nutrient uptake and utilization, increased autophagy, abnormal bud morphology, increased chronological lifespan, and decreased stress resistance including hyperosmotic and ionic stress. The protein localises to the cytosol, nucleus, and protein aggregate center. Studies of related genes in other species connect the family to oxidative stress response.