mid1 — Schizosaccharomyces pombe 972h-

Summary

SPCC4B3.15 (mid1) on chromosome 3 of Schizosaccharomyces pombe 972h- encodes a protein with a PH domain that acts as a cytoskeletal protein-membrane anchor, binds PtdIns(4,5)P2, and has phase separation nucleator activity. The gene is associated with division plane positioning, mitotic cytokinesis site selection, contractile ring assembly, and septin ring organization. It is linked to spindle breakdown, microtubule dynamics and shortening, centromere separation, and the spindle assembly checkpoint. The product localizes to the actomyosin contractile ring, medial ring, nuclear envelope, and nucleus, and is also associated with the midsome. Broader associations include regulation of cell division and cytokinesis, FAD transport, and the septation initiation network (SIN).