MUS81 — Schizosaccharomyces pombe 972h-

Summary

SPCC4G3.05C (MUS81) in Schizosaccharomyces pombe 972h- encodes a protein of the XPF/Mus81 family, possessing 3' flap endonuclease, endodeoxyribonuclease RUS and DNA-binding activities, and is localised to the nucleus, mitochondria and replication forks. The gene is associated with the resolution of recombination intermediates, meiotic joint molecule formation, double-strand break repair via break-induced replication, interstrand crosslink repair, replication fork arrest, DNA topological change, kinetochore assembly, and responses to UV and hydroxyurea. Phenotypic associations link MUS81 to mitotic and meiotic recombination, cell cycle progression (including G1/S and G2/M transitions, anaphase and telophase), chromosome segregation, sporulation, vegetative growth, thermotolerance, gamma ray resistance, vacuolar distribution, chemical compound excretion, mating type switching, and lifespan. Studies of related genes in other species connect the family to cell cycle progression in S phase and interactions with RAD10, YEN1, SMC6 and TDP1.