RGF1 — Schizosaccharomyces pombe 972h-

Summary

SPCC645.07 (RGF1) in Schizosaccharomyces pombe 972h- encodes a protein with DH, PH, DEP, and CNH domains, and is annotated for phosphatidylinositol-4-phosphate binding, lipid binding, and GDS activity. The gene is associated with regulation of cytokinesis, mitotic division septum assembly, cell wall organization, ascospore wall beta-glucan biosynthesis, abscission, cell integrity MAPK cascade, bipolar cell polarity establishment, and cell growth mode switching. It localizes to the division septum, actomyosin contractile ring, cell cortex, and spore wall. Phenotypic associations include decreased septum formation and cytokinesis rate, increased thermotolerance and virulence, abnormal cell cycle progression, delayed spore germination, and altered pheromone sensitivity. Studies of related genes in other species link Rho1 GEFs to cell wall integrity and morphogenesis pathways.