MAE1 — Schizosaccharomyces pombe 972h-

Summary

SPCC794.12C (MAE1, also known as mae2) on chromosome 3 of Schizosaccharomyces pombe 972h- encodes a malic enzyme with malate dehydrogenase (decarboxylating) activity (NADP+ and NAD+), oxaloacetate decarboxylase activity, and NAD binding. The protein localises to mitochondria, the mitochondrial lumen, cytosol, nucleus, and hydrogenosome. MAE1 is associated with malate metabolism, C4-dicarboxylate and malate transport, ethanol anabolism, malolactic fermentation, carbon catabolite repression, fermentation, pH reduction, secretion, and signal transduction. Phenotypic associations include decreased anaerobic, fermentative, and respiratory growth; increased protein secretion; decreased gamma ray, freeze-thaw, and ionic stress resistance; increased innate thermotolerance; increased cold sensitivity; decreased sporulation and filamentous growth; absent invasive growth and carbon source utilisation; abnormal cell shape, size, and budding pattern; decreased autophagy and mitotic recombination; and abnormal endoplasmic reticulum morphology.