OS-4 — Schizosaccharomyces pombe 972h-

Summary

SPAC1006.09 (OS-4, win1) in Schizosaccharomyces pombe 972h- on chromosome 1 encodes a mitogen-activated protein kinase kinase kinase (MAPKKK) of the Ssk2/Ssk22 family with MEKK activity (EC 2.7.11.25) and protein serine/threonine kinase activity. The gene is associated with the stress-activated MAPK cascade, p38 cascade, cell integrity MAPK cascade, and regulation of mitosis, meiosis II, sporulation, contractile ring assembly, fungal-type cell wall organization, nuclear transport, and response to oxidative stress. It localizes to the Mcs4 RR-MAPKKK complex, spindle pole bodies, division septum, cell tip, and cytoplasm. Phenotypic associations include absent osmotic stress resistance and innate thermotolerance, decreased cell cycle progression, abnormal prion inheritance, and sterile mating. Studies of related genes in other species link the family to virulence, pathogenicity, and stress responses.