ARP2 — Schizosaccharomyces pombe 972h-

Summary

SPAC11H11.06 (ARP2, arp2) on chromosome 1 of Schizosaccharomyces pombe encodes a protein with an actin/actin-like conserved sequence and an ATPase N-terminal domain, and is a structural constituent of the cytoskeleton, binds F-actin, and has hydrolase activity and ATP binding. The gene is associated with actin filament branching, nucleation, fragmentation, and severing, as well as contractile ring assembly, actin cortical patch assembly, endocytic recycling, membrane fission and invagination, vesicle scission, and receptor-mediated endocytosis. It localises to the Arp2/3 protein complex, the actin cytoskeleton, actomyosin contractile ring layers, and the perinuclear region. Phenotypic associations include decreased rates of cytokinesis, axial and bipolar budding, and endocytosis, abnormal cell cycle progression, filamentous growth, shmoo formation, and prion inheritance, as well as absent innate thermotolerance and decreased cell fusion and pheromone sensitivity. Studies of related genes in other species link the family to delayed cytokinesis and abnormal chitin deposition.