SMC5 — Schizosaccharomyces pombe 972h-

Summary

SPAC14C4.02C, also known as smc5 or SMC5 in Schizosaccharomyces pombe 972h- on chromosome 1, encodes a structural maintenance of chromosomes protein 5 that possesses ATPase activity acting on DNA, damaged DNA binding, and ATP hydrolase activity. The protein contains Rad50/SbcC_AAA and P-loop_NTPase domains and localizes to the Smc5-Smc6 complex, spindle pole body, sites of double-strand breaks, division septum, telomeric regions, and the nucleus. SMC5 is associated with numerous biological processes including chromosome condensation, centromere separation, meiotic prophase I, recombinational repair, DNA replication checkpoint, sumoylation, spindle assembly checkpoint, and regulation of telomere maintenance. Phenotypic associations link the gene to delayed cell cycle progression, increased mutation frequency, decreased radiation resistance, abnormal spindle pole body positioning, and altered meiotic recombination timing. Studies of related genes in other species connect the SMC5 family to the MHF1, MHF2, and SMC6 complexes.