TEM1 — Schizosaccharomyces pombe 972h-

Summary

SPAC1565.06C, also known as TEM1 or spg1 in Schizosaccharomyces pombe 972h- on chromosome 1, encodes a small GTPase of the Tem1/Spg1 family with GTPase activity, GTP binding, protein kinase regulator activity, signaling adaptor activity, and protein kinase binding. This gene is associated with cleavage furrow formation, positive regulation of vacuole fusion, regulation of signaling, primary cell septum hydrolysis, cell cycle transition, positive regulation of formin-nucleated actin cable assembly, septum digestion after cytokinesis, upregulation of TORC2 signaling, septin ring disassembly, spindle orientation, breakdown, and positioning, endosome vesicle fusion, and protein localization to the PAS and meiotic spindle pole body. It localizes to the transport vesicle membrane, cleavage furrow leading edge, recycling endosome, internal side of plasma membrane, early and late endosome membranes, meiotic spindle pole, cortical dynamic polarity patch, and growing cell tip. Phenotypically, it is linked to cell cycle progression delays and arrests, abnormal cytoskeleton morphology, chromosome segregation defects, decreased redox state, abnormal mating response, and increased pexophagy. Related genes in other species associate it with GTPase activity (EC 3.6.5.2).