scd1 — Schizosaccharomyces pombe 972h-

Summary

SPAC16E8.09 (scd1, also known as SpCDC24) on chromosome 1 of Schizosaccharomyces pombe encodes a protein with DH, PH, PB1 and CH domains and is annotated with GDS and lipid binding molecular functions. The gene product is associated with regulation of cytoskeleton and mitotic spindle organization, bipolar cell polarity establishment, division septum assembly, conjugation with cellular fusion, and endocytosis. It localizes to the cell cortex at growing tips, the cleavage furrow, division septum, and mating projection tip. The gene is linked to traits including potassium concentration, acid sensitivity, and oxidative stress response. Phenotypic associations include abnormal bipolar budding, increased mating efficiency and shmoo formation, decreased septum formation, premature G2/M transition, and altered pheromone sensitivity and production. Studies of related genes in other species link the family to the Cdc42 GTPase complex.