CDC45 — Schizosaccharomyces pombe 972h-

Summary

SPAC17D4.02, also known as cdc45 or CDC45 in Schizosaccharomyces pombe 972h- on chromosome 1, encodes the sna41 protein, a DNA replication origin-binding factor with ssDNA and chromatin binding activities. The gene is associated with mitotic DNA replication preinitiation complex assembly, pre-RC assembly, meiotic S phase, premeiotic DNA replication, regulation of DNA replication, replication fork arrest, double-strand break repair via break-induced replication, DNA replication checkpoint, intra-S DNA damage checkpoint, and DNA replication initiation. It localizes to the pre-IC, nuclear replication fork, chromatin, cytosol, and nucleus. Phenotypic associations include abnormal cell cycle progression (increased rate, delayed G2 phase, premature G1/S transition), abnormal mating type switching, increased gamma ray resistance, delayed vegetative growth, increased sporulation, premature endocytosis, delayed mitophagy, abnormal chronological lifespan, premature chromosome segregation, and arrested meiosis and metaphase-anaphase transition.