dma1 — Schizosaccharomyces pombe 972h-

Summary

SPAC17G8.10C, the Schizosaccharomyces pombe gene dma1 on chromosome 1, encodes a RING-type E3 ubiquitin ligase (EC 2.3.2.27) with a forkhead-associated (FHA) domain and zinc-binding activity. The product localises to the spindle pole body, mitotic actomyosin contractile ring, division septum, and the cell cortex of growing cell tips. It is associated with the mitotic spindle checkpoint, spindle orientation and positioning, microtubule dynamics, and the downregulation of bipolar cell growth and septation initiation signalling. The gene is also linked to positive regulation of sporulation, meiosis II, membrane assembly, septin ring disassembly, and the maintenance of cell polarity. Related genes in other species encode FHA domain and RING-type E3 ubiquitin transferase proteins.