HH3 — Schizosaccharomyces pombe 972h-

Summary

SPAC1834.04 (HH3, hht1) on chromosome 1 of Schizosaccharomyces pombe 972h- encodes a histone H3/CENP-A family protein with a histone-fold domain. The product is a structural constituent of chromatin that binds nucleosomal DNA and exhibits protein heterodimerization activity and chromatin adaptor function. It localises to the nucleosome, kinetochore, heterochromatin and subtelomeric heterochromatin. The gene is associated with centromere localisation, kinetochore assembly, mitotic metaphase chromosome alignment, sister chromatid biorientation, anaphase, S phase, mating-type switching, heterochromatin boundary formation, centromeric silencing, DNA damage response, DNA replication, proteolysis and methylation. Phenotypic associations include altered cell cycle progression (delayed mid-anaphase, decreased S-phase rate, premature metaphase-anaphase transition), increased sporulation and meiosis, decreased hypoosmotic stress resistance, increased gamma ray resistance, and abnormal mitophagy and pheromone-induced cell cycle arrest.