DCP2 — Schizosaccharomyces pombe 972h-

Summary

SPAC19A8.12 (DCP2) on chromosome 1 of Schizosaccharomyces pombe encodes a NUDIX hydrolase domain-containing protein with m(7)GpppN-mRNA hydrolase and diphosphatase activities. The gene is associated with RNA decapping, both deadenylylation-dependent and -independent pathways, nonsense-mediated mRNA decay, and RNA surveillance. It is linked to P-body and stress granule assembly, mRNA stabilization and breakdown, cellular homeostasis, positive regulation of RNA polymerase II transcription initiation, and response to heat. The protein localizes to the cytoplasm, nucleus, P-bodies, stress granules, and the Dcp1-Dcp2 complex. Studies of related genes in other species link the family to mRNA decapping enzyme activity.