clr2 — Schizosaccharomyces pombe 972h-

Summary

SPAC1B3.17, symbol clr2, on chromosome 1 of Schizosaccharomyces pombe 972h-, encodes a protein belonging to the Clr2 family, characterized by Clr2_N and Tscrpt-silencing_Clr2_C domains. The gene is associated with chromatin silencing, including centromeric, telomeric, and silent mating-type cassette chromatin silencing, as well as rDNA heterochromatin assembly and chromatin organization. It is linked to mating type switching, donor selection, gene conversion, and PTGS (post-transcriptional gene silencing). Additional associations include DNA replication, methylation, and DNA-dependent transcription. The product localizes to centric heterochromatin, subtelomeric heterochromatin, mating-type region heterochromatin, rDNA heterochromatin, and CENP-A containing chromatin. Related genes in other species link the family to the SHREC complex.