RAD3 — Schizosaccharomyces pombe 972h-

Summary

SPAC1D4.12, also known as RAD3 or rad15, encodes a member of the RAD3/XPD helicase family, possessing 5'-3' DNA helicase activity, ATP hydrolase activity, and binding capabilities for damaged DNA, ATP, and 4Fe-4S clusters. In Schizosaccharomyces pombe, this gene is associated with the response to ionizing radiation and UV, DNA integrity checkpoint functions, regulation of DNA repair, and maintenance of DNA replication fidelity. It is linked to the holo TFIIH and NEF3 complexes and localizes to chromatin, the nucleus, and sites of double-strand breaks. Phenotypic associations include altered cell cycle progression, particularly in S and G2 phases, decreased UV resistance, abnormal meiotic recombination, and defects in mating-type switching and spore germination. The gene is also connected to respiration rate and aggression-related processes.