RHO1 — Schizosaccharomyces pombe 972h-

Summary

SPAC1F7.04 (RHO1) on chromosome 1 of Schizosaccharomyces pombe encodes a small GTPase of the Rho family, possessing GTPase activity, GDP and GTP binding, protein ser/thr kinase activator activity, and signaling adaptor activity. RHO1 is associated with cell wall beta-glucan and alpha-glucan biosynthesis, cleavage furrow ingression, contractile ring contraction, bipolar cell growth, and positive regulation of formin-nucleated actin cable assembly. It localizes to the exocytic vesicle, cleavage furrow, cellular bud, and 1,3-beta-glucan synthase complex. Phenotypic associations include decreased septum formation, absent cell fusion, abnormal bipolar budding, decreased budding, absent mating type switching, decreased cell cycle progression in S phase, and sterile phenotype. Studies of related genes in other species link the RHO1 family to loss of pathogenicity, reduced virulence, acid sensitivity, and oxidative stress response.