PRP2 — Schizosaccharomyces pombe 972h-

Summary

SPAC20H4.09 (SpPRP2, also known as PRP2, PRP22, PRP43) on chromosome 1 of Schizosaccharomyces pombe encodes a DEAH-box helicase with 3'-5' RNA helicase activity, ATP hydrolase activity, and mRNA binding. The gene is associated with spliceosome complex disassembly, formation of catalytic spliceosomes for both transesterification steps, and mRNA splicing via the spliceosome. It is linked to chromosome separation, nuclear division, cell cycle control, meiosis, mitosis, S phase, and regulation of gene expression, as well as maturation of SSU-rRNA and translation initiation. Localisation evidence places the product in the spliceosome, nucleolus, and chromatin. Phenotypic associations include abnormal carbon source utilization, delayed chromosome segregation, increased X-ray resistance, altered mating response, and defects in cell cycle progression through G2/M and S phases. Related genes in other species link the helicase to spliceosomal RNA release.