TS — Schizosaccharomyces pombe 972h-

Summary

SPAC21E11.03C (Ts, SpTS) on chromosome 1 of Schizosaccharomyces pombe encodes a bZIP transcription factor with DNA-binding transcription activator activity, sequence-specific DNA binding, and nucleosome binding, and is also annotated as a recombination hotspot binding protein and chromatin adaptor. The gene is associated with activation of reciprocal meiotic recombination, suppression of meiotic recombination, chromatin looping, nucleosome organization, mitotic recombination, meiosis II, cell cycle checkpoint, silent mating-type cassette chromatin silencing, nonsense-mediated mRNA decay, nuclear import, deoxyribonucleotide anabolism, cellular homeostasis, osmotic response, glucose effect, and negative regulation of antisense RNA transcription and adenylate cyclase-activating glucose-activated G protein-coupled receptor signaling. It localizes to heterochromatin, chromatin, the mitotic spindle, and the nucleus, and is linked to calcium sensitivity and oxidative stress response. Studies of related genes in other species connect the family to reduced virulence.