PUB1 — Schizosaccharomyces pombe 972h-

Summary

SPAC23C11.03 (symbol PUB1, also known as mpp1) on chromosome 1 of Schizosaccharomyces pombe 972h- encodes a member of the Mpp10 protein family. The gene is associated with a wide range of cellular processes, including ubiquitin-mediated endocytosis, TORC2 signaling, amino acid import, SSU-rRNA maturation, deubiquitination, regulation of cell growth, dephosphorylation, cell cycle control, DNA damage checkpoint, protein ubiquitination, cytokinesis, anaphase, meiosis, mitosis, hypersensitivity, membrane transport, and endocytosis. The encoded product localizes to the Mpp10 complex, sno(s)RNA-containing ribonucleoprotein complex, SSU processome, nucleolus, cytosol, and nucleus. Phenotypic associations include abnormal cell cycle progression, altered pheromone sensitivity and cell cycle arrest, changes in nucleus size, chromosome segregation defects, abnormal septum formation, altered critical cell size at the G1 checkpoint, and increased virulence. Studies of related genes in other species link the family to RNA-binding and Sec16-related domains.