PHOD — Schizosaccharomyces pombe 972h-

Summary

SPAC23D3.12 (PHOD, SpPHOD) on chromosome 1 of Schizosaccharomyces pombe encodes a major facilitator superfamily (MFS) transporter with a sugar transporter domain. The protein has transmembrane transporter activity for glycerol-3-phosphate, glycerophosphodiesters, selenite, phosphate, manganese ions, and carboxylic acids. It is associated with phosphate homeostasis, polyphosphate metabolism, and response to nutrient availability. The gene product localizes to the plasma membrane, vacuolar membrane, Golgi, and endoplasmic reticulum. Phenotypic associations link PHOD to altered cell cycle progression, including delayed passage through START and the metaphase-anaphase transition, as well as changes in biofilm formation, spore germination, desiccation resistance, and increased survival in stationary phase. The gene is also connected to abnormal vacuolar distribution, increased aneuploidy, and altered respiratory metabolism. Studies of related genes in other species link the family to phosphate content and sodium accumulation.