ARK1 — Schizosaccharomyces pombe 972h-

Summary

SPAC23H4.17C (ARK1, also known as srb10) on chromosome 1 of Schizosaccharomyces pombe encodes a cyclin-dependent kinase (CDK) with RNA polymerase II C-terminal domain S5 and S2 kinase activities (EC 2.7.11.23 and 2.7.11.22), as well as transcription coactivator activity. The protein localises to the nucleus, euchromatin, the Mediator complex and the CDK holoenzyme. ARK1 is associated with chromosome segregation, centrosome duplication, kinetochore assembly, chromosome condensation, sister chromatid segregation, meiosis II, telophase, microtubule shortening, TORC2 signalling, galactose-specific flocculation, cellular homeostasis, non-stop decay and protein destabilisation. Phenotypic associations include delayed G2 phase cell cycle progression, arrested S phase, decreased cytokinesis, abnormal filamentous and pseudohyphal growth, decreased mating-type switching, decreased pheromone sensitivity, increased recovery from pheromone-induced arrest, decreased endocytosis, increased polyploidy, decreased necrotic cell death and abnormal prion state.