DBF2 — Schizosaccharomyces pombe 972h-

Summary

SPAC24B11.11C (DBF2, sid2) on chromosome 1 of Schizosaccharomyces pombe encodes a serine/threonine protein kinase of the AGC kinase family, with protein kinase activity (EC 2.7.11.1) and identical protein binding capability. The gene is associated with cleavage furrow ingression, actomyosin organization, and mitotic cytokinesis checkpoint control. It is linked to cell cycle transition, upregulation of mitotic spindle elongation, upregulation of nuclear migration during mitotic telophase, stem cell differentiation, and upregulation of filamentous growth of a population of unicellular organisms in response to heat. The product localizes to the spindle, actomyosin contractile ring, spindle pole body, and growing cell tips. Phenotypic associations include absent septum formation, delayed chromosome segregation, decreased lifespan, abnormal bipolar budding, and altered cell cycle progression through the G1/S phase transition, G2/M phase transition, and metaphase-anaphase transition. Studies of related genes in other species link it to the Sid2-Mob1 complex.