fft3 — Schizosaccharomyces pombe 972h-

Summary

fft3 (SPAC25A8.01C) on chromosome 1 of Schizosaccharomyces pombe encodes a member of the SNF2/RAD54-like family of ATP-dependent chromatin remodelers, possessing helicase and DNA translocase activities as well as histone H3-H4 dimer loading, nucleosome array spacer, and histone octamer slider activities. The gene is associated with nucleosome organization, heterochromatin boundary formation, transposable element silencing, attachment of telomeric heterochromatin to the nuclear envelope, and CENP-A-containing chromatin assembly. fft3 is linked to the SHREC, SWI-SNF, and PBAF complexes, and localizes to heterochromatin islands, rDNA heterochromatin, and subtelomeric heterochromatin. Phenotypically, the gene has been connected to abnormal mitotic recombination, decreased chromosome segregation, altered telomere length, absent UV resistance, increased X-ray resistance, and cell cycle arrest at the G1/S phase transition.