SMC2 — Schizosaccharomyces pombe 972h-

Summary

SPAC27D7.02C (SMC2) in Schizosaccharomyces pombe 972h- encodes a GRIP and coiled-coil domain-containing protein. The gene is associated with numerous cell cycle processes, including chromosome condensation, mitotic chromosome segregation, spindle assembly, and meiotic progression through diplotene, prophase, metaphase, and telophase. It is linked to centromere separation, DNA condensation and metabolism, the spindle assembly checkpoint, and Golgi-to-plasma membrane protein transport. Phenotypic associations include abnormal cell fusion, colony size, cell cycle progression (particularly in anaphase and metaphase), premature meiosis, absent sporulation efficiency, increased gamma ray resistance and virulence, decreased polyploidy, delayed vegetative growth and mitotic cell cycle, and increased fermentative growth. The protein localises to the Golgi complex, cytoplasm, and cytosol. Related genes in other species encode structural maintenance of chromosomes proteins.