SET2 — Schizosaccharomyces pombe 972h-

Summary

SPAC29B12.02C, also known as SET2, encodes a histone methyltransferase (EC 2.1.1.359) with histone H3K36 methylase, dimethylase and trimethylase activities, and RNA binding capability. It contains SET, AWS, Post-SET and SRI domains characteristic of the Set2 family. In Schizosaccharomyces pombe, SET2 is associated with DNA-templated transcription elongation and termination, chromatin silencing, nucleosome organization, co-transcriptional chromatin reassembly, DNA replication licensing, suppression of meiotic recombination, centromere localization, and the DNA integrity checkpoint. It is linked to long non-coding RNA and snoRNA transcription, negative regulation of antisense RNA transcription, base excision repair, and non-homologous end joining. Phenotypically, SET2 is associated with cell cycle progression through G2/M and G1/S phase transitions, delayed G2 phase, increased S phase progression, delayed cell cycle start, meiotic recombination delay, meiosis arrest, abnormal mating response, absent nuclear fusion during mating, increased sporulation, decreased spore germination, increased transposable element transposition, polyploidy, altered carbon source utilization, absent fermentative growth, absent alkaline pH resistance, and premature endocytosis. The protein localizes to the nucleus, chromatin, chromosome, and cytosol.