ARK1 — Schizosaccharomyces pombe 972h-

Summary

SPAC2E1P5.05 (ARK1, also known as rrp9) in Schizosaccharomyces pombe 972h- encodes an uncharacterized WD repeat-containing protein belonging to the Rrp9-like family, featuring WD40 repeat domains. The product binds U3 snoRNA and snoRNA, and also exhibits GTP binding. ARK1 is associated with numerous cellular processes including regulation of chromosome segregation, centrosome duplication, kinetochore assembly, sister chromatid segregation, chromosome condensation, spindle checkpoint function, meiosis II, telophase, microtubule shortening, TORC2 signaling, and flocculation. It localizes to the nucleolus, cytoplasm, nucleus, spliceosomal complexes, SSU processome, and histone methyltransferase complex. Phenotypic associations include decreased cytokinesis, delayed G2 phase cell cycle progression, decreased endocytosis, abnormal filamentous growth, decreased mating type switching, increased polyploidy, and decreased resistance to chemicals. Studies of related genes in other species link the family to cell membrane stability, protein content, and phosphate content.