RAD52 — Schizosaccharomyces pombe 972h-

Summary

SPAC30D11.10, designated rad52 in Schizosaccharomyces pombe 972h- on chromosome 1, encodes the Rad22 protein, a member of the Rad52/Rad59/Rad22 superfamily. The product possesses DNA reannealing, DNA end binding, recombinase, damaged DNA binding, double-stranded DNA binding, single-stranded DNA binding, identical protein binding, and protein-bridging activities. It is associated with double-strand break repair via single-strand annealing, resolution of recombination intermediates, meiotic joint molecule formation, strand invasion, meiotic cell cycle control, DNA integrity checkpoint, regulation of mitotic recombination, DNA amplification, pre-RC assembly, rDNA maintenance, class switching, V-J joining, single-strand break repair, and response to acetaldehyde and CPT. The protein localizes to the nucleus, nuclear chromosome, chromatin, mitochondria, and sites of double-strand breaks. It is also linked to oxidative stress response.