rad55 — Schizosaccharomyces pombe 972h-

Summary

SPAC3C7.03C, the rad55 gene of Schizosaccharomyces pombe 972h- on chromosome 1, encodes a protein with ATP-dependent DNA damage sensor activity and ATP hydrolase activity, binding both DNA and ATP. It belongs to the RecA ATP-binding domain and P-loop NTPase families. The gene is associated with meiotic DNA recombinase assembly, joint molecule formation, strand invasion, and reciprocal meiotic recombination, as well as mitotic recombination and double-strand break repair. It is linked to mating type switching, DNA replication and damage checkpoints, and mitotic S phase. The product localizes to the BCDX2 and CX3 complexes, replication forks, and sites of double-strand breaks, as well as the cytosol and nucleus.