POL1 — Schizosaccharomyces pombe 972h-

Summary

POL1 (SPAC3H5.06C) on chromosome 1 of Schizosaccharomyces pombe encodes a protein with DNA-directed DNA polymerase activity (EC 2.7.7.7) and 3'-5' exonuclease activity, and is associated with 4Fe-4S cluster binding and chromatin binding. The gene is associated with DNA replication initiation, leading and lagging strand elongation, Okazaki initiator RNA removal, and base-excision repair and nucleotide-excision repair. POL1 localises to the alpha DNA polymerase:primase complex, nuclear replication forks, telomeric repeat regions, and sites of double-strand breaks. Phenotypic associations link the gene to cell cycle progression through G1/S and G2/M phase transitions, S phase duration, chromosome segregation, meiotic recombination, sporulation, and chronological lifespan. The gene also shows associations with telomere length and pheromone sensitivity. Studies of related genes in other species support the family's conserved role in replication and genome stability.