tup11 — Schizosaccharomyces pombe 972h-

Summary

SPAC3H5.08C (tup11) on chromosome 1 of Schizosaccharomyces pombe encodes a WD repeat-containing protein of the WDR44/Dgr2 family, with transcription corepressor activity, GTF2 activity, histone binding, and GTP binding. It is associated with mRNA transcription and capping, transcription initiation from RNA polymerase II promoters, and both upregulation and downregulation of DNA-dependent transcription, as well as negative regulation of transcription by RNA polymerase II. The gene is linked to response to salt, salinity response, flocculation, gluconeogenesis, the glucose effect, iron transport, exocytosis, signal transduction, and hypersensitivity. It localizes to the transcription factor TFIID complex, SAGA complex, histone methyltransferase complex, mitotic spindle pole body, cell tip, chromatin, cell division site, Golgi complex, ER membrane, and cytosol. Related genes in other species are linked to the Tup11/Tup12 repressor complex.