pabp — Schizosaccharomyces pombe 972h-

Summary

SPAC57A7.04C, the pabp gene on chromosome 1 of Schizosaccharomyces pombe 972h-, encodes a poly(A)-binding protein (PABP) characterized by multiple RRM domains and a PABP_HYD region. The protein exhibits poly(A) and poly(U) binding, mRNA 3'-UTR binding, RNA nuclease inhibitor activity, phase separation nucleator activity, and promoter-specific chromatin binding. It is associated with diverse mRNA metabolism processes including 3'-end processing, poly(A) tail shortening, pre-mRNA decay, transport, translational initiation and elongation, and stress granule assembly. The gene is linked to responses to glucose, heat, and general stress, as well as constitutive heterochromatin assembly, chromatin silencing, cytokinesis, and nuclear import. The protein localizes to the nucleus, cytoplasm, cytosol, ribosome, stress granules, and post-mRNA release spliceosomal complexes. Related genes in other species are linked to lethal phenotypes.