rad9 — Schizosaccharomyces pombe 972h-

Summary

SPAC664.07C (rad9) on chromosome 1 of Schizosaccharomyces pombe encodes a protein belonging to the Rad9/Ddc1 family and the DNA clamp superfamily. The product possesses protein kinase activator activity and signaling adaptor activity. Rad9 is associated with the DNA integrity checkpoint, the cellular response to ionizing radiation, and the mitotic DNA damage checkpoint. It is associated with recombinational repair, replication fork arrest, establishment of sister chromatid cohesion, telomere capping, rDNA maintenance, the spindle checkpoint, and programmed cell death. The protein localizes to the nucleus, cytoplasm, chromatin, telomeric repeat regions, and sites of double-strand breaks. Studies of related genes in other species link the family to DNA damage checkpoint control.