KAR3 — Schizosaccharomyces pombe 972h-

Summary

SPAC664.10, also known as KAR3 or klp2 in Schizosaccharomyces pombe 972h- on chromosome 1, encodes a kinesin-like protein with minus-end-directed microtubule motor activity (EC 5.6.1.4) and ATP hydrolase activity. The gene is associated with numerous microtubule-related processes, including spindle assembly, breakdown, and stability during both mitosis and meiosis, as well as microtubule bundling, sliding, and anchoring at the spindle pole body. It is linked to nuclear migration, chromosome movement, and dendrite development. Phenotypic associations include abnormal colony size, altered cell cycle progression (including premature or delayed transitions through G1/S, G2/M, metaphase, and anaphase), increased sporulation, decreased lifespan, and abnormal nuclear fusion during mating. The gene product localizes to microtubule plus- and minus-ends, the kinesin I complex, and astral microtubules. Studies of related genes in other species further connect this gene family to microtubule dynamics and cell division.