cut9 — Schizosaccharomyces pombe 972h-

Summary

SPAC6F12.15C (cut9, also known as CDC16) in Schizosaccharomyces pombe 972h- encodes a tetratricopeptide repeat (TPR) domain-containing protein with enzyme-substrate adaptor activity. It localises to the cyclosome, cytoplasm, and centric heterochromatin. The gene is associated with numerous cell cycle processes, including mitotic sister chromatid separation, centromere separation, spindle elongation, and the metaphase-anaphase transition. It is also linked to chromosome condensation, proteasome localisation, spore wall assembly, and spore germination. Phenotypic associations include cell cycle arrest at multiple phases (G1/S, G2, metaphase-anaphase, telophase), premature or absent chromosome segregation, defective meiosis and meiotic recombination, decreased nuclear fusion during mating, and absent spore wall formation.