orb6 — Schizosaccharomyces pombe 972h-

Summary

SPAC821.12 (orb6) on chromosome 1 of Schizosaccharomyces pombe encodes a serine/threonine protein kinase (EC 2.7.11.1) belonging to the AGC-kinase family, with protein kinase, ATP-binding and identical protein binding activities. The gene is associated with stem cell differentiation, negative regulation of protein localization to the medial cortex, exocyst localization, mating projection assembly, regulation of protein secretion, actomyosin organization, lipid raft organization, the mitotic cytokinesis checkpoint, positive regulation of primary cell septum biogenesis, microtubule nucleation, and positive regulation of filamentous growth. It is also linked to upregulation of nuclear migration during mitotic telophase, mitotic spindle elongation, actomyosin contractile ring contraction, and filamentous growth in response to heat. The product localizes to the Sid2-Mob1 complex, actomyosin contractile ring, growing cell tip, hyphal tip, cytoskeleton, cellular bud tip, meiotic spindle pole body, and spindle pole body. Related genes in other species include CBK1, linking the family to cell polarity and morphogenesis.